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The following services may be available for use in clinical studies by prior arrangement; further details are available on request. Please note that the availability of services is dependent on our current research programmes.
Assays are available for the measurement of the following drugs:
· Anti-HIV drugs (amprenavir, atazanavir, darunavir, efavirenz, indinavir,
lopinavir, nelfinavir, nevirapine, ritonavir, saquinavir, tipranavir)
· Anti-TB drugs (rifampicin, isoniazid, ethambutol)
Note, the anti-HIV drug assays are covered by an external QA scheme.
Method development for analysis of other drugs by LC-MS/MS or HPLC considered.
Metabolic studies of licensed drugs or drugs in development:
· Determination of the role of transport proteins in drug disposition
using cells models and molecular techniques.
· Antiviral testing in chronically and acutely infected cells.
· Pharmacogenomic studies, e.g. phenotype-genotype for drug
disposition genes.
Data analysis:
· Determination of pharmacokinetic parameters
· PK-PD modelling of anti-HIV and anti-TB drugs
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